The San Francisco 49ers are dealing with a rash of injury issues entering their Week 2 matchup with the New Orleans Saints.

The team is off Monday and Tuesday, then they'll be back on the practice field Wednesday. The 49ers and Saints will kick off at 10:00am Pacific Time from the Superdome in New Orleans. More 49ers: ...

The San Francisco 49ers defeated the Seattle Seahawks on Sunday, and defensive end Nick Bosa gave a lot of credit to his ...

The San Francisco 49ers defeated the Seattle Seahawks on Sunday. Here's who had the best and worst days, according to Pro Football Focus.

The San Francisco 49ers have been very thin at wide receiver throughout the preseason and into Week 1. Now, they're bringing in more help.

Riding high off the win, the 49ers turned around and gave starting offensive tackle Colton McKivitz a three-year, $45 million extension with $27 million guaranteed, according to ESPN's Adam Schefter.

The San Francisco 49ers and Seattle Seahawks met for their season opener on Sunday. Here are a few 49ers who shouldn't be happy with their day.